Network Engineering

Shvartsman drosophila embryos

The Shvartsman lab uses drosophila embryos, such as the ones shown here, to study enzyme cascades in early development.

Intracellular signaling pathways act as the major transducers of information within the cell. Understanding and manipulating these pathways is the focus of network engineering (sometimes called systems biology). Network engineering often involves a combination of experimental and computational approaches to explore the connections between molecules in complex reaction networks, such as those involved in metabolism.

Recent work:

Metabolic control of persister formation in Escherichia coli (Molecular Cell)

Princeton University’s core faculty members in this area:

Jose Avalos
Mark Brynildsen
Sabine Petry
Josh Rabinowitz
Stas Shvartsman
Jared Toettcher